Click once on the game so your mouse controls where you look. Press Esc to get your mouse back.
W forward, S back, A left, D right. Space jumps. Move the mouse to look around. Hold Shift to run.
Point the little + at a block and keep holding the left button until it pops. Walk over the little block that drops to pick it up.
Press a number to pick something from the bar at the bottom. Right-click where you want to put it down.
E opens your bag. On the right is a list of things to make. Green rows mean you have enough stuff. Click one to make it!
Pick food on your bar and hold the right button. The little drumsticks are your hunger. Hearts are your health.
Press H any time to see this page again.
The box in the top-left tells you what to do next. In Easy mode a yellow arrow floats over the thing you need.